In 1989, Manisha moved to Mumbai to pursue a career in Bollywood. She made her debut with the film "Sanskritik" (1990), but it was her second film, "Saajgah" (1991), that brought her to the attention of critics and audiences alike. Her early years in Bollywood were marked by a string of successful films, including "Bol Radha Bol" (1992) and "Raja Hindustani" (1996), which earned her her first Filmfare Award for Best Actress.

In addition to her film work, Manisha Koirala has been a part of various entertainment content, including television shows and web series. She has made appearances in popular TV shows like "The Anupam Kher Show" and "Koffee with Karan," where she has shared her insights and experiences with the audience.

Her filmography is defined by a blend of major commercial blockbusters and critically acclaimed artistic roles.