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The cytokine storm—characterized by elevated IL-6—triggers capillary leak, alveolar edema, and hypoxemia. Tocilizumab blocks membrane-bound and soluble IL-6 receptors, thereby dampening this cascade. ABG provides a real-time, objective measure of respiratory and metabolic function. Understanding the temporal relationship between Tocilizumab infusion and ABG changes is critical for intensive care and rheumatology settings.

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